(1951 - )
Directora General del Instituto "Finlay", Centro de Investigación y Producción de Vacunas y Sueros. Es una de las creadoras de VA-MENGOC-BC, la primera y única vacuna en el mundo con eficacia comprobada contra el meningococo tipo B.
Biomedical Sciences
1989 | Risk factors and technological advances in hemorrhagic dengue fever.
Main author: María Guadalupe Guzmán Tirado
Summary: Some clinical-epidemic retrospective studies in patients that suffered hemorrhagic dengue fever during the epidemic of 1981 and seroepidemiological studies carried out in the municipalities of Cerro, Cienfuegos and Guantanamo, allowed evidencing diverse risk factors in the severe form of this disease: feminine sex, childhood, white race and antecedents of bronchial asthma and diabetes mellitus (these 3 last, not previously reported). Experimental studies corroborated these observations. There were known the attack rates to 1 and 2 Dengue viruses in the epidemics of 1977 and 1981, through the above-mentioned seroepidemiological studies, and it was corroborated the role of the sequential infection as a very important risk factor in the production of an Epidemic of hemorrhagic dengue fever. Some isolation techniques of these viruses have been incorporated; an ELISA system has been developed for the detection of total immunoglobulins to dengue, which is applied in the seroepidemiological surveillance in the country, and several monoclonal antibodies have been developed and generated, which allow the identification and purification of the agents of this disease. PERFORMERS: Institute of Tropical Medicine "Pedro Kourí"