(1903 - 1975)
Pedagogo e historiador. Su obra cumbre, Historia de Cuba, de gran valor didáctico, constituye un texto de obligada consulta para todos los que se acerquen al estudio del proceso de desarrollo económico, político y social de la mayor de las Antillas.
Biomedical Sciences
1996 | Novel modifications for Uhlmann-Goldberg reaction
Main executives entity:  Center for Pharmaceutical Chemistry
Main author: Rolando Fermín Pellón Comdom
Summary: Uhlmann-Goldberg synthesis allows obtaining a vast amount of chemical compounds that, for their diversity, have a wide use in the medical-pharmaceutical industry. N- Phenylanthranilic acids, all the derivatives of acridines and acridones, xanthones and thioxanthones, phenothiazines and others, which have been and are still valid as antinflammatory, antiarthritic, antibacterial, schistosomiasic, antitumoral, are examples of this. The original procedure has been catalogued by prestigious authors as having “more art than science” for its high complexity when isolating and purifying the products, as well as for the variability and instability of the results from a laboratory to another. The modifications developed in these works allowed, in the first place, reducing the costs of obtaining the products when substituting organic solvents of high boiling point by water; clarifying a scientific controversy about the poisoning of catalysts by water; obtainig products with a higher purity degree when the formation of colored compounds is minimized; systematizing the isolation and purification procedures, also making them easier; and shortening the reaction time with the introduction of catalysts. All this has been traduced in patents, 14 publications, 21 presentations in events, 1 doctoral thesis, 2 master’s degree and 4 university diploma theses. The procedure has been applied to the development of techniques to obtain several commercial antinflammatory, antiarthritic and antidepressant products. Part of these results was Main Achievement CQF and CENIC/95. The results from the last ten years of work are presented.
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