(1860 - 1912)
Médico. Su obra científica en el campo de la Urología lo consagra como uno de los más importantes especialistas de esa disciplina a escala mundial. Innovó y perfeccionó la técnica instrumental, contribuyendo a preservar la salud de pacientes con afecciones renales.
Biomedical Sciences
1996 | Viral meningoencephalitis by enterovirus 1991-1995
Main executives entity: "Pedro Kourí" Institute of Tropical Medicine (IPK)
Main author: Pedro José Más Lago
Summary: The results of the enterovirus study are described as responsible for Viral meningoencephalitis (MEV), from 1990 to 1995. 586 samples of feces, 108 of cerebrospinal fluids and 1 095 of paired serums were studied in this period, for a total of 1 789 samples, coming from 1 458 patients clinically diagnosed with this pathology. The samples for viral isolation were inoculated in two different cellular systems, and 225 samples were positive to enterovirus that represent 32.42% of the total; the highest number of isolations (217) was starting from feces, in diploid cells of fibroblasts of human lung (PHuE-1). The determinations of antibodies were carried out by neutralization test in micromethod, with 10 enterovirus antigens (Echovirus 4, 6, 9, 11 and Coxsackievirus B1-6) and in epidemic periods also with the isolated virus. There were produced, in the studied years, three epidemic outbreaks by Coxsackievirus A9 (1990-1991), Echovirus 30 (1994) and Coxsackievirus B5 (1995). It is remarkable that it is linked in Cuba, for the first time since1970, to MEV, Coxsackievirus A9 and Echovirus 30 epidemics. It was obtained 66.84% positive in paired serums, with the highest positivity for Echovirus 6 and 11. When considering positivity as a whole for isolation and serology, more than 80% of the studied cases could have an explanation for some enterovirus, which demonstrates the importance of these agents as responsible for MEV in our environment.
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