(1916 - 1978)
Médico cirujano. Contribuyó al desarrollo de la cirugía experimental y del trasplante de órganos en Cuba. Se dedicó también a los estudios de Cibernética aplicada a la Medicina y gran parte de su esfuerzo lo consagró a la urgente tarea de reformar los hospitales universitarios y al propio Plan de estudios de la Facultad de Medicina.
Biomedical Sciences
1999 | Identification of the biochemical and immunological effect from Cry1Ac toxin of Bacilus thurigiencis in mammals
Main author: Roberto I. Vázquez Padrón.

One of the most used bioinsecticides is Bacillus Thuringiensis, which produces the “Cry proteins” during the sporulation process. These proteins constitute active elements against larvas of invertebrate species (insects, nematodes and protozoans)

The biochemical characteristics high molecular weight, high resistance to proteolyses, solubility and stability in extreme pH, common with very immunogenic proteins, make out of these elements possible candidates for the development of bovine relevant epitopes' carriers.

The adjuvant properties were demonstrated with the surface antigen of hepatitis B in mice Balb/C and with an inactivated Auyeski virus in guinea pigs. The discovery of these properties from the studied proteins sustains the possibility to use them as adjuvants or vectorial proteins in the production of new vaccines for veterinary or human use and in the optimization of others already existent.

The facility to produce these Cry proteins offers considerable economic advantages over other adjuvants nowadays used.

Another part of the work describes the interaction of Cry1Ac protoxin with the border in brush of the mouse's small intestine. This discovery is very important because the Cry proteins are part of the food elaborated with some transgenic plants and the studies carried out show once again its innocuousness, in a way before unexplored.

It is attached a granted Cuban patent (ONPI 99-105) and 3 works published in international magazines Biochemistry and Molecular Biology International (1998), Life Science (1999) and Scand. J. of Immunol (1998).