Anaplasma marginale is the causal agent of bovine anaplasmosis, infectious hemoparasitic desease affecting cattle and causing severe economic losses, while it is difficult to use vaccines due to the great pathogen variability.

The study deals with the msp 1B isolation (related to one of the proteins with which it could be possible to protect cattle), of cuban isolated from different regions in the island, obtaining a recombinant protein which was used as catheter to find the cuban strains polymorphic patterns, proving thus the existence of a mspB high polymorphism, as well as the presence of the gen multigenic family. Two of these genes are transcribe during the desease acute phase, suggesting the expression of the different proteins during the desease stages, whhich should be taken into account in the vaccines further development.

The obtained results have the greatest scientific exellence and the following supports from: Scientific Council of: National Center for Farming Sanity (CENSA), Finlay Institute , Center for Biotechnology and Genetic engineering (CIGB), Dr. Esther Orozco, Professor and Researcher of the Center for Research and Advanced Studies of the National Polytechnical Institute of México.

There are publication supports of results in:

• · Infection and Inmunity Journal 2000: 1946 - 1952;
• · IX International Congress of Parasitology, Chiba Japon, 24 - 28 August, 1998;
• · Biotecnología Aplicada (Applied Biotechnology)1996, 23 (1): 39;
• · Rev. De Salud Animal (Animal Health Journal) 1995: 17: 159 - 165;
• · Doctorate Thesis to obtain the degree of Dr. in Sciences oin Genetics and Molecular Biology, from Center for Research and Advanced Studies of the National Polytechnical Institute of México;
• · !st National Congress of Tropical Medicine, Puebla October 7 -9, 1999;
• · 15th Panamerican Congress of Veeterinarian Sciences Mato Groso do Sul Brasil;
• · 12th National Congress of Parasitology XII CONAPAR 96 Aguas Calientes 96;
• · 13th Latin and American Congress of Parasitology. Havana, November 17 – 23, 1997;
• · Biotecnología Habana (Biotechnology Havana) 95.

the result has relevance, excellence and scientific novelty and pave the way to the obtention of vaccines against this important parasite.