An inhibitor effect of the Dialyzable Extract of Leukocytes is demonstrated on the transcriptional essential factors for the HIV genic expression. It is described, for the first time, the inhibition by the EDL of the union activity from NF-kB to its specific sequence of DNA, as well as its suppressive effect on the Sp1 transcriptional activity. These results clarify observations previously carried out, such as the inhibition effect by the EDL of HIV replication in cultivation cells and the inhibition in peripheral leukocytes of the secretion of TNFa induced by LPS.

Most of the patients infected with HIV who have received EDL for a long time, have shown a decrease on the disease's progress, with clinical and laboratory parameters' improvement. The experimental explanation obtained by the authors about the mechanisms of action of EDL provides new bases to impel the diffusion of this product and its clinical use. It has been published this work in an important magazine.