

Using a correct scientific methodology, the authors demonstrate what was postulated in the title, making original scientific contributions with those that support the effectiveness obtained by the vaccine in the clinical-epidemic field.
The work contains great scientific interest and its results are profitable for the creation of new vaccines. The authors use a leading-edge technology in the attainment of their objectives. These results have been published in the Infection and Immunity magazine (2 articles) in 2001. Likewise, they have been presented 4 times in international events in Cuba and in France. They have been, also, the subject of 3 thesis works.