(1832 - 1886)
Abogado y profesor. Notable escritor sobre temas de Jurisprudencia, Literatura y Filosofía. Publicó importantes artículos sobre Derecho, Literatura y Filosofía a partir de 1850 en las más importantes publicaciones periódicas de la época.
Biomedical Sciences
2002 | Application of percolation theory to the design of a modified release system of Lobenzarit di-sodium.
Main author: Anailién Boza Rivero.

Historically, the design of modified release ways has been approached from the traditional methodology of "test and error", or using the principles of the experimental design. These equations have limited practical use and it is required a large amount of experimental work. In 1991, Leuenberger applies for the first time the Percolation Theory to optimize inert dot matrix formulations of modified release of pharmacos, when developing equations that allow calculating the thresholds of percolation of pharmacos and exicipients. The main practical limitation lies in the need to carry out dissolution tests to constant surface, and for that it is necessary to cover the pills with a paraffin pellicle before subjecting it to the test.

In this work, there are used for the first time the concepts of this theory to optimize a controlled release formulation for lobenzarit di-sodium, an antiarthritic pharmaco synthesized by the Pharmaceutical Chemistry Center (CQF) . It is also carried out a scientific contribution to Leuenberger and Bonny method. The work is important to the world pharmaceutical industry. From the practical point of view, with the new method it is possible to develop, in shorter time, dot matrix systems of controlled release and it is avoided the elaboration of unnecessary lots, and therefore raw material is saved. From the scientific point of view, an undeniable contribution is made to the already novel Leuenberger and Bonny mathematical method, when allowing the use of equations directly from the dissolution tests traditional in industry, to variable surface.

This work is endorsed by 4 articles in prestigious specialized international magazines (3 in Int. J. Pharm. Adv., 1 in Pharmaceutical Sciences), 4 in books of summaries from international scientific events and 18 reports in national events.