(1903 - 1975)
Pedagogo e historiador. Su obra cumbre, Historia de Cuba, de gran valor didáctico, constituye un texto de obligada consulta para todos los que se acerquen al estudio del proceso de desarrollo económico, político y social de la mayor de las Antillas.
Biomedical Sciences
2003 | Immunogenic potential of Dengue 4 virus casing protein expressed through recombinant via in Pichia pastoris
Main executives entity: "Pedro Kourí" Institute of Tropical Medicine (IPK).  (1) , Center for Biotechnology and Genetic Engineering (CIGB)(2)
Main author: Mayra Mune y Rayner Rodríguez.
Coauthors: Del (1) Guadalupe Guzmán, Rosa Ramírez, Rosmary Rodríguez, Mayling Alvarez, Delfina Rosario, Susana Vázquez, Beatria, Yudira Soto, Katia Valdés,  Maritza Pupo, Gisset García, Teresita Serrano, María E. Moreno y Tania Pumariega; del (2) Gerardo Guillén, Lisset Hermida, Gabriel Márque, Laura Lazo, Rolando Páez, Raúl Martínez, José García, Carlos López y Rafael Espinosa
Summary:

The presented work essentially consists on Pichia pastoris clonning and expression of the gene encoding E glycoprotein in Dengue 4 virus casing and the evaluation of its protecting immunogenicity and induction in mice and non-human primates. This protein is the responsible of the virus-cell link, and also induces virus neutralizing antibodies and viral amplification mediating antibodies.

The work´s sicnetific novelty consits on the expression of a recombinant E protein truncated by its terminal carboxyl portion with a modified glycosilation. It is however capable of generating protection against Dengue 4 virus in mice and non-human primates. This protection is correlated to neutralizing antibodies induction and a cellular immunoresponse, what is for the first time reported in the international scientific community.

There is an international patent request and 4 publications in foreign journals of impact, which denotes international acceptance of its contribution to the efforts in develooping a safe and effective vaccine against Dengue.

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