Gonococcal infection is an important health problem in Cuba and the world in the context of sexual transmitted deseases and in the same epidemiological area in which AIDS develops.

Due to the high desease frequency and the indiscriminated use of antibiotics, the presence of resistant strains to conventional antimicrobial therapy have become usual bringing about serious social and economic repercussion.

The objectives of this research were to study antimicrobial and plasmid profile sensitivity of Neisseria gonorrhoeae strains from 11 provinces in Cuba and evaluate factors influencing on antimicrobial resistance of the studied germ.

In order to reach these objectives molecular markers were used, which allowed to establish different genetic patterns sensible to antibiotics. A high percentage of conventional antibiotherapy resistant strains was evident: penicillin (68 %), tetracyclin  (83.5 %), and combined resistance (49.5 %).

On the other hand, the total WHO recomended strains sensitivity antibiotics was objectified, what have helped to decrease the number of reported cases from 45,200 in 1995 to 14,792 lin 2001.

Five works have been presented in relevant journals on the issue and a chapter in a WHO book in 2000.