

It is about the development of the active, standardized and valid principle of two pharmaceutical forms of VIMANG product: tablets of 300mg and ointment 1.2%. This work describes the results of the researches undertaken, the technological development and the medical applications of these two pharmaceutical forms.Active principle chemical composition was determined,which main fraction is the one of polyphenols with the glucosilxanton manguiferine as mayoritary component. Such extract posses antioxidant effect as well as protection against oxidative damage , inhibition of inflammatory processes and analgesic effect on in vivo experimental models. Toxicologic studies proved it is about a safe product for human consumption; while the clinical studies showed a significant correlation in oxidative stress markers.
The product has sanitary register for pain-included or inflamatory deseases. The worked is supported by 11 international scientific publications. It also has trade mark and industrial property in Cuba and some other countries.
It counts on supports of: Institute of Pharmacy and Food of the University of Havana, Center for Research and Development of Drugs, IPK, Salvador Allende Hospital and the Medical Services of the Revolutionary Armed Forces, as well as the University of Chile, University of Ancona and University of Salermo, these two last ones in Italy.
It is a technology inserted and developed by Cuban Medical and Pharmaceutical Industry, which is generalized by the Ministry of Public Health.