(1838 - 1904)
Zoólogo, botánico y médico. Desarrolló una amplia labor en la Real Sociedad Económica de Amigos del País de La Habana. Autor de un depurado estilo literario, dio a conocer numerosas contribuciones científicas.
Biomedical Sciences
2004 | Original study on the usefulness of a protein fragment conforming dengue viruses covering as a possible vaccinal candidate against dengue
Main executives entity: "Pedro Kourí" Institute of Tropical Medicine-IPK, Center for Biotechnology and Genetic Engineering -CIGB
Main author: Rayner Rodríguez Díaz del IPK y Lisset Hermida Cruz del CIGB
Coauthors: Del CIGB: Aida Zulueta, Carlos López, Laura Lazo, Gerardo E. Guillén, Iris Valdés, Jorge Martín, Ricardo Silva, Rafael Martínez, Glay Chinea, Jorge Sánchez, Jorge Castro, Manuel Selman, Gabriel Márquez, Karelia Cosme, Raúl Espinosa; del IPK: Mayling Alvarez , María G. Guzmán, Beatriz de la C. Sierra, Lidice Bernardo, Rosmari Rodríguez, Delfina Rosario, Irina Prado, Susana Vázquez, Ana B. Pérez

This work constitutes the first international scientific report on the evaluation of a flavovirus covering protein in monkeys and forsees its utility as vaccinal subunity. It is also the first study with fusion proteins using a carrier protein already validated in clinic assay, which allows it to be used in humans. This work reports protection against viremia development, what has not been fulfilled before with other immunogens. It is a part of one of the most prioritized macroprojects in our country. The development of a vaccine against dengue constitutes a great contribution since this desease is one of the major health risks for most of the world population.

This research defines new molecular entities resulting immunogenic and pathogenic in a desease to which effective vaccines are not reported yet.

These results conform a part of the national efforts to obtain a vaccine against dengue, placing Cuba among the leading contries in dengue basic and applied research . It has 4 publications and a request of patent presented in PCT, USA and several Latin American countries in 2002. Results have been presented in 6 international scientific events with 25 works presented.