(1900 - 1964)
Médico. Fundador del Instituto de Medicina Tropical, cúspide de su actividad científica y docente, llevada a cabo con dedicación y trabajo abnegado en la investigación de la Parasitología.
Biomedical Sciences
2005 | Membrane lipids act as modulators of Sticholisine II permiating activity , a porous forming toxine with potential biomedical applications
Main executives entity: Center for Proteins Studies, Biology Faculty, University of Havana
Main author: Diana Martínez Cruz-Bustillo, Carlos Álvarez Valcárcel, María Eliana Lanio Ruiz.
Coauthors: Mayra Tejuca Martínez, Fabiola Pazos Santos, Aisel Valle Garay, Lesly Calderón Domínguez, Uris Ros Quincoces, Iscel Díaz Hernández y David Pentón Ribas.

The reffered work develops the action characterization of the main lipidic components of the membrane on sticholisine II (St II), Stichodactyla helianthus anemone toxine, which membrenous hydrophylic porous forming function conferes it potential biomedical application, as immunotoxines formation or the release of encapsuled antigens cytosol in liposomes. In order to be able to control and manipulate this actions in a useful an effective way in biomedical applications, it is critical to know how these toxine interacts with membrane lipids for purous formation.

From the conceptual point of view, it is a relevant original contribution of this work the chance of postulating a special particular confirmation which adjusts to the toroidal porous model (helicoidal tetramers), sustained, among other evidences, by the lipidic movement through the bilayer since the insertion of toxine in the membrane.

This work´s results have had a broad dissemination in the scientific community through multiple publications in very prestigious and impacting journals, presentations in numerous high level scientific events and have been subjected to aknowledgements in national and international ambit.

This work constitutes an important scientific contribution since it provides significant contributions to create the conditions which make possible a future mastering of this system with utilitarian purposes; it also paves the way to its therapeutical applications, particularly in the Oncology field.