(1877 - 1971)
Botánico. Destacado científico que dedicó su vida a estudiar e interpretar la naturaleza cubana y a buscar nuevas fuentes de riquezas naturales; su mayor aporte a la ciencia lo constituyen sus estudios acerca de las plantas medicinales.
Biomedical Sciences
2005 | Cuban Tetravalent Trivac-HB®
Other entities: Finlay Institute (2), “Pedro Kourí” Institute of Tropical Medicine (3), Centro Nacional de Biopreparados (4), Specialist from Cienfuegos (5) and Camagüey (6)
Main author: Nestor S. Expósito Raya
Coauthors: Daniel Cardoso González (2), Eduardo Martínez Díaz(1), Pablo Arsenio Díaz(1), Jorge Luis Vega Elías(1), Yanelis Herrera (2), Gerardo E. Guillén Nieto(1), Luis Herrera Martínez(1), Verena Muzio González(1), Manuel E. Díaz Gonzalez(3), Plácido Pedroso Falquet(3), Karelia Cosme (1), Rubén Rosquete(7), Licel Rodríguez Lay(3), Daymí Guzmán Hernández(3), Nilda Alemañy Bueno(3), Teresa Lopez Regueiro(5), Lucía Fernandez Hernandez(5), Odalys Quintero Rodríguez(5), Luis Gómez(5),Rafael Francisco Sánchez(1), Orestes Mayo(4), Joel Pérez Gutierrez(4), Luis Carlos Hidalgo(4), Concepción Campa Huergo (2), Alberto Agraz Fierro(4), Marisel Quintana(1), Mabel Izquierdo López(1), Maribel Vega Simón(1), Liliana Senda Corredera(6), ,Norman Gutierrez Villa(6), Marité Bello Correrdor(3), Ramón Barberá (2), Francisco Machado(1), Manuel Silva Costa(6), Angela Fernandez Muñoz(5), Zoe Nuñez Lamotte(1), Virgilio Bourg(4), Eduardo Pentón Arias(1), Marianela García (1), Carmen Valenzuela(1), Marta Noroña (2), Aleida Mandariote (2)
Summary:

The objective was to register and insert the DPT-HB cuban combined vaccine, which is the first one in Cuba and Latin America applied with these antigens and using aluminium hydroxide adjuvant , what evades the Glaxo Smith Kline combined vaccines existing patent. Results proved that TRIVAC HB remains stable for 24 months, effective and well tolerated by children, this is why it was registered in cuba in November 2004, providing half million of doses to MINSAP and ensuring its application in March 2005. Requests from other countries have been made.

Conclussions:

Social: apply simultaneously four vaccines.

Economic: simultaneous application is more economical and gives us also a 100% vaccinated people coverage in a moment in which dpt is insuficient in the world and 500 000 doses have been given to MINSAP during this year.

Scientific: it is the second world level tetravalent vaccine evading Smith Kline patent when using aluminium hydroxide as adjuvant.

It count on the MINSAP needed supports.

All requested permises to develop the clinical assays.

CECMED register

Its evaluation was made in Cienfuegos and Camaguey having these provinces´ participation.