(1883 - 1915)
Médico epidemiólogo. Su principal aporte a la ciencia mundial fue su explicación del modo de transmisión de la fiebre amarilla: la hembra de la especie de mosquito que hoy conocemos como Aedes aegypti.
Agrarian and Fishery Sciences
2005 | Diagnosis and control of pig’s transmissible gastroenteritis for the first time in Cuba
Main executives entity: National Center of Farming Sanity (CENSA), Veterinary Medicine Institute (IMV)
Main author:

Colectivo CENSA : Maritza Barrera, María Teresa Frías, Heidy Díaz de Arce, Edisleidy Rodríguez y Ana María Acevedo

Colectivo IMV : Rafael Urquiaga, René Ramos, Nelson Rodríguez y Daymi Valdés.


Collective CENSA: Armando Vega, María Irián Percedo, Sandra Cuello, Carmen L. Perera, Reina Durán, Miguel Pérez and Lydia Tablada.

Colectivo IMV: Sergio González, Adela Encinosa, Guillermo Sánchez, Emerio Serrano and Oscar Ricardo.


Pig’s Transmissible Gastroenteritis (TGE) causes big losses in newborn litters of temperate climate countries for their high morbidity and lethality; for this reason, it was considered an unlikely exotic disease in the country. Some diarrheic manifestation similar to TGE appeared in February of 2003, with mortality rates close to the 100%. This work embraces the researches that allowed its identification, the development of methods and means of diagnosis and the design and execution of a control program, and it is considered a significant contribution to know TGE and the ethology of pig’s diseases in Cuba.

There were carried out some researches in order to: determine, for the first time in Cuba, TGE presence through the virus characterization by electronic microscopy techniques and RT-PCR; identify TGE virus as causal agent of diarrheic syndrome, the phylogenetic dendrogram as a result from the molecular characterization and viral genotypification, to determine its homology with an isolation from Mid-West USA; obtain the stump of national enteropathogenic reference and a method for the experimental reproduction of TGE clinical signs, very valuable for in vivo assessments of vaccines and antiviruses; develop and standardize diagnostic methods (immunocytochemical, RT-PCR, viral isolation, seronaturalization) to elaborate diagnosis means of strategic value for their systematization, replacing other commercials’ importation.

It was carried out the serologic monitoring through ELISA, to know the epizootiologic situation of this disease to national level. IMV and CENEDI’s specialists were trained for the extension of primary diagnosis, and it was created a prevention and control program for Cuba, and the plan of corresponding measures. Some users’ references are enclosed. It has a reference from the Center of Veterinary Diagnosis of the University of Nebraska and it received the Recognition of Cuban Minister of Agriculture. The results have been published in five scientific magazines, two of which are foreign magazines very prestigious in this subject.